Gene
a functional unit in the genome, that requires transcription for its function (this encompasses protein and non-protein coding units and their cis-acting regulatory elements.)
Homologous genes
represent genes that are inherited in different species and share a common ancestor (homologous genes are of course to some extent related in sequence, but similar sequences not
necessarily represent homologous sequences/genes).
Orthologous genes
homologous genes that share a common ancestor and have the same (main) function
Functional unit:
the entity, whose absence or presence or alteration causes a phenotype
Allele:
a variant version of a gene at the very same locus with an altered DNA code
Phenotype:
any detectable difference caused by a change in the DNA code of a gene
(in practice this means: every phenotype is inseparably linked to the assay conditions,
under which it can be detected. It is rarely possible to show that a mutation does not
cause an „altered phenotype". To be rigorous, also a mutant background is an "assay"
and synthetic phenotypes are phenotypes.)
Dominant/
recessive:
terms to describe the relation of alleles of the same gene
(a recessive allele will only be effective if homozygous; a dominant allele will be effective irrespective of
the nature of the other allele(s))
Epistasis:
describes the relation between an allele of a gene (at one locus) and the
allele(s) of a another gene (at a different locus)
(an allele at locus "a" is epistatic to a gene at locus "b" if the phenotype is determined
by the given allele at locus "a" independent of "b's" allelic version(s))
Genome:
The entire genetic information of an organism (add on for
eukaryotes: that resides in the nucleus).
Mouse
3,4x10^9 bp 20 Chromosomes
Zebra fish
1,4x10^9 bp 25 Chromosomes
C. elegans
1x10^8 bp 6 Chromosomes
D. melanogaster
1,2x10^8 bp 4 Chromosomes
A. thaliana
1,3x10^8 bp 5 Chromosomes
S. cerevisiae (Hefe)
1,2x10^7 bp 16 Chromosomes
E. coli
4,6x10^6 bp 1 Chromosome