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Gene

a functional unit in the genome, that requires transcription for its function (this encompasses protein and non-protein coding units and their cis-acting regulatory elements.)

Homologous genes

represent genes that are inherited in different species and share a common ancestor (homologous genes are of course to some extent related in sequence, but similar sequences not

necessarily represent homologous sequences/genes).

Orthologous genes

homologous genes that share a common ancestor and have the same (main) function

Functional unit:

the entity, whose absence or presence or alteration causes a phenotype

Allele:

a variant version of a gene at the very same locus with an altered DNA code

Phenotype:

any detectable difference caused by a change in the DNA code of a gene

(in practice this means: every phenotype is inseparably linked to the assay conditions,

under which it can be detected. It is rarely possible to show that a mutation does not

cause an „altered phenotype". To be rigorous, also a mutant background is an "assay"

and synthetic phenotypes are phenotypes.)

Dominant/

recessive:

terms to describe the relation of alleles of the same gene

(a recessive allele will only be effective if homozygous; a dominant allele will be effective irrespective of

the nature of the other allele(s))

Epistasis:

describes the relation between an allele of a gene (at one locus) and the

allele(s) of a another gene (at a different locus)

(an allele at locus "a" is epistatic to a gene at locus "b" if the phenotype is determined

by the given allele at locus "a" independent of "b's" allelic version(s))

Genome:

The entire genetic information of an organism (add on for

eukaryotes: that resides in the nucleus).

Mouse

3,4x10^9 bp 20 Chromosomes

Zebra fish

1,4x10^9 bp 25 Chromosomes

C. elegans

1x10^8 bp 6 Chromosomes

D. melanogaster

1,2x10^8 bp 4 Chromosomes

A. thaliana

1,3x10^8 bp 5 Chromosomes

S. cerevisiae (Hefe)

1,2x10^7 bp 16 Chromosomes

E. coli

4,6x10^6 bp 1 Chromosome